Comparison of body composition and of biochemical parameters in sham operated controls fed a standard chow (Sham-L, n=14) or a HFD (Sham-DIO, n=15) and in mice subjected to a vertical sleeve gastrectomy (VSG) fed the HDF (VSG-DIO, n=11). (A) Time-course of the experiment 1. (B) OGTT two days before then two weeks after surgery. (C) Evolution of body weight after surgery. (D) Fat mass, glycemia, plasma cholesterol and LPS levels. Mean ± SEM, Wilcoxon and Mann-Whitney tests: ns non-significant, * p < 0.05, ** p < 0.01, *** p < 0.001. DIO, diet induced obese; HFD, high fat diet; L, lean; LPS, lipopolysaccharides; OGTT, oral glucose tolerance test.