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. 2021 Apr 16;13(4):697. doi: 10.3390/v13040697

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparing anti-SARS-CoV-2 IgG, IgA, and IgM responses to S protein and RBD antigens in asymptomatic, non-hospitalized, and hospitalized resolved subjects. (A) Anti-S protein IgG, IgA, IgM, and (B) anti-RBD IgG, IgA, and IgM of the asymptomatic (n = 11), non-hospitalized resolved subjects (n = 134) and hospitalized resolved subjects (n = 8) were profiled using the SARS-CoV-2 ELISA. Values are shown as a ratio of observed optical density to the determined assay cut-off optical density. All hospitalized subjects had detectable anti-S protein IgG, anti-RBD IgG, and anti-S protein IgA antibodies in their serum. The levels of anti-S protein and anti-RBD IgG (mean OD_405nm ratio) in resolved subjects who were hospitalized were significantly higher than the non-hospitalized resolved population. Values above 1 ratio are considered positive in the SARS-CoV-2 ELISA. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0005.