Table 2.
miRNAs and their target genes, differentially expressed in the placental bed samples from women with IUGR < 34 according to the data of miRNA deep sequencing and mass spectrometry.
| miRNA | log2(FC) * | p ** | Gene-Target Name | Protein Name (Protein ID, UniProtKB) |
log2(FC) * | p ** |
|---|---|---|---|---|---|---|
| hsa-miR-1-3p | 1.18 | 0.00012 | ANXA2 | Annexin A2 (P07355) | −2.15 | <0.0001 |
| hsa-miR-1-3p | 1.18 | 0.00012 | TAGLN2 | Transgelin-2 (P37802) | −2.088 | <0.0001 |
| hsa-miR-1-3p | 1.18 | 0.00012 | YWHAZ | 14-3-3 protein zeta/delta (P63104) | −1.032 | 0.00193 |
| hsa-miR-1-3p | 1.18 | 0.00012 | FN1 | Fibronectin (P02751) | −6.999 | 0.00504 |
| hsa-miR-199a-3p | 0.72 | 0.00026 | FN1 | Fibronectin (P02751) | −6.999 | 0.00504 |
| hsa-miR-199b-3p | 0.72 | 0.00027 | FN1 | Fibronectin (P02751) | −6.999 | 0.00504 |
| hsa-miR-185-3p | −0.95 | 0.00060 | FLNA | Filamin-A (P21333) | 0.9255 | 0.1388 |
| hsa-miR-128-3p | 0.80 | 0.0024 | FN1 | Fibronectin (P02751) | −6.999 | 0.00504 |
| hsa-miR-140-3p | −0.71 | 0.0025 | DSTN | Destrin (P60981) | 0.878 | 0.00531 |
| hsa-miR-30c-5p | 0.62 | 0.0075 | FBN1 | Fibrillin-1 (P35555) | −6.985 | 0.0689 |
| hsa-miR-30c-5p | 0.62 | 0.0075 | VIM | Vimentin (P08670) | −1.695 | 0.0012 |
| hsa-miR-30c-5p | 0.62 | 0.0075 | YWHAZ | 14-3-3 protein zeta/delta (P63104) | −1.032 | 0.00193 |
| hsa-miR-28-3p | 0.56 | 0.0140 | VIM | Vimentin (P08670) | −1.695 | 0.0012 |
| hsa-miR-30d-5p | −0.59 | 0.02025 | MYH11 | Myosin-11 (P35749) | 1.9163 | <0.0001 |
| hsa-miR-654-3p | 0.57 | 0.0421 | FGA | Fibrinogen alpha chain (P02671) | −7.686 | 0.0002243 |
| hsa-miR-15b-5p | −0.53 | 0.0495 | MYL6 | Myosin light polypeptide 6 (P60660) | 1.5447 | 0.000172 |
* log2(FC) = logarithm value to base two of median fold change (FC) in the expression level of miRNA or target gene. ** p = statistical significance of the expression level of miRNA or target gene.