Table 4.
Pairwise comparison of the IUGR, PE, SGA, and N groups by the expression level ratio of miRNA and its target gene, obtained by RT-PCR in each of the studied placental bed samples.
| miRNA/mRNA Pair | Groups to Be Compared 1 | p-Value | |
|---|---|---|---|
| IUGR > 34 | N > 34 | ||
| miR-28-3p/VIM | −4.74 (−5.79, −4.22) |
−2.49 (−3.48, −2.43) |
0.001 |
| miR-654-3p/FGA | −0.81 (−3.93, 0.83) |
4.43 (2.46, 9.85) |
0.006 |
| miR-15b-5p/MYL6 tr.v.2 | 2.13 (1.02, 2.5) |
3.32 (2.7, 3.72) |
0.006 |
| miR-15b-5p/MYL6 tr.v.1 | 1.57 (1.53, 2.46) |
3.29 (2.87, 3.9) |
0.0007 |
| miR-1-3p/ANXA2 | −5.78 (−8.25, −5.23) |
−4.13 (−5.04, −2.61) |
0.037 |
| miR-1-3p/YWHAZ | 1.09 (−0.55, 2.43) |
4.28 (2.39, 5.73) |
0.03 |
| miR-30c-5p/FBN1 | −2.73 (−3.7, −2.55) |
0.24 (−1.53, 0.79) |
0.02 |
| miR-30c-5p/YWHAZ | 2 (0.89, 2.63) |
5.81 (3.84, 6.43) |
0.006 |
| miR-30c-5p/VIM | −4.61 (−5.18, −4.32) |
−2.37 (−3.2, −1.18) |
0.006 |
| SGA > 34 | N > 34 | ||
| miR-654-3p/FGA | −1.46 (−2.5, 1.18) |
4.43 (2.46, 9.85) |
0.006 |
| PE > 34 | N > 34 | ||
| miR-654-3p/FGA | −1.84 (−2.88, 0.1) |
4.43 (2.46, 9.85) |
0.001 |
| miR-185-3p/FLNA | −0.49 (−0.66, 0.13) |
1.4 (0.53, 1.93) |
0.0026 |
| miR-30c-5p/YWHAZ | 2.82 (1.55, 3.39) |
5.81 (3.84, 6.43) |
0.0026 |
| IUGR > 34 | SGA > 34 | ||
| miR-30c-5p/VIM | −4.61 (−5.18, −4.32) |
−3.16 (−3.78, −2.87) |
0.016 |
| miR-15b-5p/MYL6 tr.v.1 | 1.57 (1.53, 2.46) |
2.58 (2.1, 3.06) |
0.01 |
| miR-30c-5p/FBN1 | −2.73 (−3.7, −2.55) |
−1.62 (−1.98, −0.98) |
0.02 |
| PE > 34 | IUGR > 34 | ||
| miR-15b-5p/MYL6 tr.v.2 | 2.8 (2.74, 3.29) |
2.13 (1.02, 2.5) |
0.001 |
| miR-15b-5p/MYL6 tr.v.1 | 3.22 (2.31, 3.29) |
1.57 (1.53, 2.46) |
0.0046 |
1 Data on a logarithm to base two of the expression level ratio of miRNA and its gene target mRNA, presented as a median of (ΔCt(mRNA) − ΔCt(miRNA)) values, and quartiles Q1 and Q3 in the Me (Q1; Q3) format with an indication of the statistical significance (p) using the Mann–Whitney test.