Table 2.
Dysregulated lipids in the inner VSMCs region of symptomatic plaques. Species with a VIP score greater than one and with a loading on the first PLS axis exceeding the 90th percentile of the positive or negative values are reported.
| Matrix | Dysregulation in Symptomatic | m/z | Δppm | Adduct | Assignment |
|---|---|---|---|---|---|
| DHB | ↑ | 369.35 | 5 | [M+H-H2O]+ | Cholesterol |
| DHB | ↑ | 671.575 | 1 | [M+H]+ | CE(20:5) |
| DHB | ↑ | 671.575 | 1 | [M+Na]+ | CE(18:2), zymosteryl oleate, 16:1 Stigmasteryl ester, 16:2 Sitosteryl ester |
| DHB | ↑ | 687.55 | 4 | [M+Na]+ | TG(38:1) |
| DHB | ↑ | 725.555 | 2 | [M+Na]+ | SM(34:1), PE-Cer(37:1) |
| DHB | ↑ | 741.53 | |||
| DHB | ↑ | 758.57 | 0 | [M+H]+ | PC(34:2), PE(37:2) |
| DHB | ↑ | 780.55 | 1 | [M+Na]+ | PC(34:2), PE(37:2) |
| DHB | ↑ | 782.565 | 2 | [M+Na]+ | PC(34:1), PE(37:1) |
| DHB | ↑ | 796.525 | 0 | [M+Na]+ | PE(P-40:7),1-(8-[3]-ladderane-octanoyl)-2-(8-[3]-ladderane-octanyl)-sn-glycerophosphoethanolamine |
| DHB | ↑ | 798.54 | 1 | [M+Na]+ | PE(P-40:6) |
| DHB | ↑ | 808.58 | 3 | [M+Na]+ | PC(36:2), PE(39:2) |
| Nor. | ↑ | 780.555 | 1 | [M+H]+ | PC(36:5), PE(39:5) |
| Nor. | ↑ | 780.555 | 4 | [M+Na]+ | PC(34:2), PE(37:2) |
| Nor. | ↑ | 808.585 | 0 | [M+H]+ | PC(38:5), PE(41:5) |
| Nor. | ↑ | 808.585 | 0 | [M+H-H2O]+ | PS(O-40:4), PS(P-40:3) |
| Nor. | ↓ | 808.585 | 2 | [M+Na]+ | PC(36:2), PE(39:2) |
| DHB | ↓ | 697.475 | 4 | [M+Na]+ | PA(34:1) |
| DHB | ↓ | 773.505 | 1 | [M+H-H2O]+ | all-trans-nonaprenyl diphosphate |
| DHB | ↓ | 778.605 | |||
| DHB | ↓ | 832.58 | 3 | [M+Na]+ | PC(38:4), PE(41:4) |
| DHB | ↓ | 837.68 | 2 | [M+Na]+ | SM(42:1) |
| DHB | ↓ | 946.615 | |||
| Nor. | ↓ | 723.54 | 1 | [M+Na]+ | SM(34:2), PE-Cer(37:2) |
| Nor. | ↓ | 835.67 | 4 | [M+Na]+ | SM(42:2) |