Figure 1.

Analyses of differentially expressed genes in human keratinocytes treated with melatonin, 6-hydroxymelatonin and AFMK. Venn diagrams are in (A) for up- and in (B) for downregulated genes. Heatmaps for all upregulated genes are in (C) and for downregulated genes in (D), which are common for all tested compounds. Keratinocytes were treated with 10⁻⁵ M of melatonin, its metabolites or vehicle for 24 h and submitted for RNA-sequence analysis.