Table 3.

Univariate and multivariable Cox proportional hazard analysis for overall survival.

	Univariate Hazard Ratio (HR) (95% Confidence Interval (CI))	p-Value *	Multivariable HR	p-Value *
			(95% CI)
Colon
Age-adjusted comorbidity index score (ACCI)
Low	1	<0.001	1	<0.001
Intermediate	1.30 (1.02–1.66)		1.50 (1.17–1.92)
High	2.70 (2.21–3.30)		3.24 (2.65–3.98)
Gender
Male	1	0.032	1	0.026
Female	0.84 (0.71–0.98)		0.82 (0.69–0.97)
UICC stage
I	1	<0.001	1	<0.001
II	1.25 (0.97–1.63)		1.31 (1.00–1.73)
III	1.53 (1.18–1.20)		1.71 (1.29–2.26)
IV	7.34 (5.47–9.83 )		8.75 (6.38–11.99)
Type of surgical resection
Elective major surgery	1	<0.001	1	<0.001
Emergency surgery	2.21 (1.72–2.83)		1.82 (1.41–2.35)
Local excision	1.36 (0.75–2.48)		1.90 (1.0–3.62)
Adjuvant chemotherapy
No	1	0.254	_
Yes	0.90 (0.76–1.07)
Side of colon
Right	1	0.141	1	0.077
Left	0.88 (0.75–1.04)		0.86 (0.72–1.02)
Time periods
2000–2005	1	0.707
2006–2010	0.96 (0.79–1.17)		_
2011–2015	0.96 (0.77–1.19)
Rectum
ACCI
Low	1	<0.001	1	<0.001
Intermediate	1.81 (1.33–2.45)		2.25 (1.65–3.07)
High	2.51 (1.89–3.34)		3.29 (2.42–4.36)
Gender
Male	1	0.320	_
Female	0.88 (0.69–1.13)
UICC stage
I	1	<0.001	1	<0.001
II	1.33 (0.98–1.80)		1.41 (1.04–1.91)
III	1.59 (1.16–2.16)		1.90 (1.39–2.60)
IV	5.51 (3.73–8.15)		8.42 (5.60–12.67)
Type of surgical resection
Elective major surgery	1	0.543	_
Emergency surgery	3.11 (1.46–6.60)
Local excision	1.01 (0.58–1.76)
Preoperative radiotherapy
No radiotherapy	1	0.296	_
Short-course (25 Gy)	0.87 (0.65–1.16)
Chemoradiotherapy (50 Gy)	1.17 (0.89–1.55)
Adjuvant chemotherapy
No	1	0.601	_
Yes	1.07 (0.83–1.39)
Time periods
2000–2005	1	0.483	_
2006–2010	1.01 (0.76–1.34)
2011–2015	0.89 (0.66–1.22)

* p for linearity.