Table 2.
Patient demographics, outcomes, and treatment specifics.
| Institution | Testing Cohort | Training Cohort | p-Value 1 |
p-Value Adjusted 1 |
|
|---|---|---|---|---|---|
| Accrual time | 2010–2016 | 2007–2015 | |||
| Total Patients | 71 p | 108 p | |||
| Primary | 66 p (93%) | 108 p (100%) | <0.001 * | <0.001 * | |
| Recurrent | 5 p (7%) | 0 p | |||
| Location | Lower Extremity | 56 p (79%) | 75 p (70%) | 0.36 | 1.0 |
| Upper Extremity | 10 p (14%) | 17 p (16%) | |||
| Trunk | 5 p (7%) | 16 p (14%) | |||
| Age | m 57 (r 17–87) | m 53.7 (r 19.1–88.5) | 0.16 | 1.0 | |
| Gender | female | 35 p (49%) | 29 (27%) | 0.005 * | 0.078 |
| male | 36 p (51%) | 76 (70%) | |||
| unknown | 0 p | 3 p (3%) | |||
| T-stage 2 | 1 | 4 p (6%) | 9 p (8%) | 0.40 | 1.0 |
| 2 | 30 p (42%) | 32 p (30%) | |||
| 3 | 23 p (32%) | 41 p (38%) | |||
| 4 | 14 p (20%) | 26 p (24%) | |||
| M-stage 2 | 0 | 71 p (100%) | 108 p (100%) | - | - |
| 1 | 0 p (0%) | 0 p (0%) | |||
| N-stage 2 | 0 | 69 p (97%) | 108 p (100%) | 0.16 | 1.0 |
| 1 | 2 p (3%) | 0 p | |||
| Grading 3 | 1 | 0 p (0%) | 0 p (0%) | 0.88 | 1.0 |
| 2 | 28 p (39%) | 44 p (40%) | |||
| 3 | 43 p (51%) | 64 p (60%) | |||
| AJCC-Stage 2 | IIA | 9 p (13%) | 15 (14%) | 0.0025 * | 0.045 * |
| IIB | 4 p (6%) | 32 (29%) | |||
| III | 48 p (68%) | 61 (58%) | |||
| Margin-status | positive | 12 p (17%) | 28 p (26%) | 0.011 | 0.18 |
| negative | 53 p (75%) | 76 p (70%) | |||
| unknown | 2 p (3%) | 3 p (3%) | |||
| no resection | 4 p (6%) | 1 p (1%) | |||
| RT type | post-operative | 15 p (21%) | 32 (29%) | <0.001 * | 0.007 * |
| neoadjuvant | 52 p (72%) | 75 p (70%) | |||
| definitive | 4 p (6%) | 1 p (1%) | |||
| Total RT Dose | m 50 Gy(r 28–70 Gy) | m 50 Gy(r 38–50Gy) | <0.001 * | <0.001 * | |
| Chemotherapy | 3/71 p (4%) | 64 p (59%) | <0.001 * | <0.001 * | |
| Median OS | 40.1 (r 6.0–105.5) | 39.9 (r 4.2–130.4) | 0.53 | 1.0 |
Abbreviations: *: p-value < 0.05, AJCC: American Joint Committee on Cancer and the International Union for Cancer Control (8th edition), m: median, p: patients, r: range, RT: radiation therapy, 1 Wilcoxon rank-sum test for continuous and ordinal variables, Fisher’s exact test for nominal variables, log-rank test for comparison of survival times. Corrected for multiple testing by Bonferroni correction (“p-value adjusted”). 2 Following AJCC staging system 8th edition [42]. 3 According to the French Federation of Cancer Centers Sarcoma Group (FNCLCC).