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Schematic of folate metabolism. Effects of reduced MTHFR activity on DNA synthesis and methylation. DHF, dihydrofolate; MTs, methyltransferases; THF, tetrahydrofolate; SAM, S-adenosyl methionine; SAH, S-adenosyl homocysteine; TS, thymidylate synthase. MTR, methionine synthase; MTRR, methionine synthase reductase.
