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. 2021 Apr 20;13(8):1981. doi: 10.3390/cancers13081981

Figure 1.

Figure 1

Overview of the Hippo signaling pathway. Hippo signaling is initiated by a variety of upstream stimuli. Activation of Hippo (MST1/2) leads to subsequent phosphorylation of LATS1/2. LATS1/2 negatively regulates the Hippo pathway effector YAP/TAZ. Unphosphorylated YAP/TAZ translocates into the nucleus where it interacts with TEAD transcription factors to upregulate the transcription of a variety of genes. In contrast, phosphorylation of YAP/TAZ leads to its cytoplasmic sequestration by 14-3-3 proteins and degradation.