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The role of YAP/TAZ in tumor immunity. YAP/TAZ expression in immune cells controls the differentiation and activities of Tregs and macrophages, which change the effector T-cell activity and tumor progression. YAP/TAZ expression in turn controls the activities and recruitment of tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), contributing to a modification of tumor progression.
