Table 5.
Interactions between compounds from Marynka hop variety and selected antibiotics.
| FICI a Index of Different Combination of Antibiotics and Hop Compounds | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Crude Extract (E1) | Xanthohumol (XN) | |||||||||
| Bacteria | gentamicin | cefepime | ceftriaxone | ciprofloxacin | sparfloxacin | gentamicin | cefepime | ceftriaxone | ciprofloxacin | sparfloxacin |
|
S. aureus
ATCC 25923 |
1.5 | 0.5 | 0.562 | 0.5 | 0.562 | 1.06 | 2 | 1.06 | 1.5 | 1.5 |
|
S. epidermidis
ATCC 12228 |
1.5 | 0.5 | 0.562 | 0.562 | 0.5 | 1.5 | 1.06 | 1.06 | 1.5 | 1.06 |
|
S. mutans
PCM 2502 |
1.5 | 0.562 | 0.375 | 0.5 | 0.375 | 1.06 | 0.5 | 0.5 | 0.562 | 1.06 |
|
S. sanguinis
PCM 2335 |
1.06 | 0.5 | 0.375 | 0.375 | 0.562 | 1.5 | 0.5 | 0.375 | 0.562 | 1.06 |
|
P. acnes
PCM 2400 |
2 | 0.562 | 0.562 | 0.562 | 0.562 | 1.5 | 0.562 | 0.562 | 1.06 | 1.06 |
|
P. acnes
PCM 2334 |
1.5 | 0.5 | 0.375 | 0.5 | 0.5 | 1.5 | 0.5 | 0.562 | 1.06 | 1.06 |
a Fractional inhibitory concentration index. FICI Index range: ≤0.5—synergy; 0.5 to 1.0—additivity; 1.0 to 4.0—indifference; >4.0—antagonism.