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. 2021 Apr 19;14(4):378. doi: 10.3390/ph14040378

Figure 5.

Figure 5

Effect of ABK5-1 and ABK5-2 on CXCL12-mediated Jurkat cell migration. Transwell migration of Jurkat cells treated with (A,B) ABK5-1 or (C,D) ABK5-2. Frames (A,C): Cells were treated with vehicle or various concentrations of test compounds for 2 h and then allowed to migrate through transwells for 2 h. Cell numbers migrated to the lower chamber are indicated as relative to vehicle (DMSO) alone. Results are indicated as the mean ± S.D. of three independent assays performed in triplicate for each concentration. Viability of cells treated with (B) ABK5-1 or (D) ABK5-2 after the migration assay was also examined. Cells were treated exactly the same but without transwells and viability was determined. Results are indicated as the mean ± S.D. of three independent assays performed for each concentration. One-way ANOVA plus Dunnett’s post-hoc test were used for both migration and viability assays. **** p < 0.0001 (versus vehicle control group).