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. 2021 Apr 19;14(4):378. doi: 10.3390/ph14040378

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of ABK5-1 on lipopolysaccharide (LPS)-induced cytokine production in microglia. BV-2 cells were pretreated with DMSO (<0.1%) or 1 or 10 μM ABK5-1 and stimulated with LPS. (A) mRNA levels of IL-1β and IL-6 after 6 h of LPS stimulation. (B) IL-1β protein concentration in the cell culture medium after 24 h of LPS stimulation. U.D. indicates under detection limit. (C) IL-6 protein concentration in the cell culture medium after 24 h of LPS stimulation. (D) Viability of BV-2 cells after ABK5-1 10 μM treatment. Results are indicated as the mean ± S.D. of three independent assays performed for each concentration. One-way ANOVA plus Dunnett’s post-hoc test were used and **** p < 0.0001 (versus reference).