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. 2021 Apr 18;22(8):4198. doi: 10.3390/ijms22084198

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Differences in lipidomic patterns in response to hyperlipidemia and sex differences in the sedentary groups. (A) Partial least squares discriminant analysis (PLS-DA) score plot of lipidomic datasets based on the whole lipidome. Dashed circles display 95% confidence regions. (B) Venn diagram displaying the number of statistically different components. (C) Differences in lipid classes, (D) increase in oleic acid-containing lipid species, (E) decrease in linoleic acid-containing lipid species, and (F) increase in arachidonic acid-containing components due to hyperlipidemia (n = 10–12 mice per group). * denotes p < 0.05. PC, diacyl phosphatidylcholine; PE, diacyl phosphatidylethanolamine; PE-P, alkenyl-acyl phosphatidylethanolamine; PG, phosphatidylglycerol; BMP, bis(monoacylglycero)phosphate; CL, cardiolipin; Carn, carnitine; DG, diacylglycerol; TG, triacylglycerol; FFA, free fatty acid.