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. 2021 Apr 20;22(8):4263. doi: 10.3390/ijms22084263

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cisplatin decreased viability of NTERA-2 CisR spheroids in combination with high concentration of PRI-724. (A) The effect of combined treatment with PRI-724 and cisplatin in NTERA-2 CisR multicellular spheroids. Relative viability was determined by luminescent viability assay on day 6. Values were expressed as the averages of hexaplicates and SD were indicated in the table. (B) Data obtained by luminometric assay were analyzed by Calcusyn software and Fa-CI plot was created. Plot displays synergism (CI < 1), additivity (CI = 1) or antagonism (CI > 1) for the entire spectrum of effects [36]. CI values were indicated in the table. CI—function of effect level, Fa—fraction affected (Fa = 1 − % of viable cells/100).