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. 2021 Apr 20;22(8):4263. doi: 10.3390/ijms22084263

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PRI-724 exhibited antitumorigenic effect on NTERA-2 CisR xenografts in vivo. (A) Outline scheme of the treatment. Cisplatin, PRI-724 and vehicle were intraperitoneally administered to mice. The timing of drug administration is indicated by arrows. (B) PRI-724 significantly inhibited the growth of NTERA-2 CisR xenografts. (C) The tumor sizes were significantly smaller in the group of mice treated with PRI-724 alone compared to control group (vehicle) or to mice treated with cisplatin. Cisplatin did not enhance antitumorigenic effect of PRI-724. (D) Images of representative tumors at the end of the experiment showing the antitumorigenic effect of Wnt/β-catenin/CBP inhibition by PRI-724. * p < 0.05, ** p < 0.01, *** p < 0.001.