Table 1.
Gene and protein expression profiles of Mg channels and transporters in humans.
| x | Expression in Normal Tissue | Expression in Cancer Tissue | |||||
|---|---|---|---|---|---|---|---|
| GTEx | Human Protein Atlas | Human Protein Atlas | TCGA | GEPIA2 | GEO Profiles | Literature | |
| TRPM6 | Mainly expressed in colon, Brain and Testis | Not detected | Not detected | Down-regulated in COAD (FC 30) | Down-regulated in CRC (FC 1.25) [37] Down-regulated in CA (FC 15) [36] |
Higher in CRC (IHC) [41] Down-regulated in CRC [43] |
|
| TRPM7 | Ubiquitous, expressed in colon | Moderate in colon, only glandular cells | No expression in 11 CRC patients | Higher in CRC (IHC) [41] Higher in CRC (IF) [42] |
|||
| MRS2 | Ubiquitous, expressed in colon | High in colon glandular cells and moderate in endothelial cells | Strong and moderate expression in 11/12 CRC patients | Down-regulated in early-onset CRC (FC 1.3) [38] Up-regulated in CA (FC 1.3) [36] |
|||
| MAGT1 | Ubiquitous, expressed in colon | High in colon glandular cells and moderate endothelial cells | Moderate expression in 10/12 CRC patients | Up-regulated in COAD (FC 2.5) | Up-regulated in CRC (mRNA) [44] | ||
| SLC41A1 | Ubiquitous, expressed in colon | High in colon glandular cells and moderate in endothelial cells | Strong and moderate expression in 12/12 CRC patients | Up-regulated in early-onset CRC (FC 2.15) [38] Up-regulated in CA (FC 1.21) [36] |
|||
| CNNM1 | Low expression in colon | Moderate expression in colon, in both glandular and endothelial cells | Low and moderate expression in 7/12 CRC patients | Down-regulated in CA (FC 1.33) [36] | |||
| CNNM3 | Ubiquitous, expressed in colon | High expression in colon glandular cells, moderate in Colon endothelial cells |
Strong and moderate expression in 12/12 CRC patients | ||||
| CNNM4 | Ubiquitous, expressed in colon | High expression in colon, only in glandular cells | Strong and moderate expression in 10/12 CRC patients | Down-regulated in COAD (FC 3.4) | Up-regulated in COAD (FC 3) | Down-regulated in CRC (FC 1.18) [37] Down-regulated in early-onset CRC (FC 1.94) [38] Down-regulated in CA (FC 2.6) [36] |
Lower in colon cancer-derived Metastases (IHC) [45] |
Abbreviations: FC: Fold Change, CA: Colorectal Adenoma, COAD: Colon Adenocarcinoma, CRC: Colorectal Cancer, IHC: Immunohistochemistry, IF: Immunofluorescence.