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Effect of ADAM12 on oncogenic signaling pathways in human CRC cells. Western blotting demonstrated that phosphorylation of PTEN decreased and Akt level increased upon ADAM12 overexpression; opposite results were observed upon ADAM12 knockdown. ADAM12, A disintegrin and metalloprotease 12; CRC, colorectal cancer; PTEN, phosphatase and tensin homolog deleted on chromosome 10; EV, EmptyV, empty-pcDNA6-myc vector; AV, ADAM12-pcDNA6-myc construct; SS, scramble siRNA; AS, ADAM12 siRNA.
