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. 2021 Apr 19;13(4):706. doi: 10.3390/v13040706

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Proteolytic targets of Flavivirus NS3. Panel (A) shows the Flavivirus RNA genomic organization encoding three structural and seven non-structural proteins. Panel (B) shows the NS3 from DENV-4 (Protease and Helicase in New Cartoon (helix-α in purple, 3₁₀ helix in blue, β-sheets in yellow, β-bridge in tan, and turn in cyan), and the zoom of the catalytic triad H51, D75, and S135 in green)). Also, cofactor NS2B (red) is shown (PDB ID: 2VBC). Panel (C) shows the cleavages of Nups by NS3pro from DENV and ZIKV.