Figure 4.

Polyprotein cleavage and structure of Enterovirus 2Apro and 3Cpro. Panel (A) shows the Enterovirus RNA genome that encodes four structural and seven non-structural proteins and the cleavage sites by 2Apro and 3Cpro. Panel (B) shows 2Apro and its catalytic triad H18, D34, and C105, from RV (PDB ID: 2M5T). Panel (C) shows 3Cpro and its catalytic triad H40, E71, and C147, from PV (PDB ID: 1L1N). Color code: helix-α in purple, 3₁₀ helix in blue, β-sheets in yellow, β-bridge in tan, and turn in cyan.