Table 3.

Mathematical release model determination by comparing the fitting parameter R². The bold underlined values represent the best fit and hence the most suitable model to describe the respective release stages for the four tested samples.

Model	Stage	3CMC3DCF1	3CMC2DCF1	3CMC3DCF2.5	3CMC2DCF2.5
ZERO ORDER	I	0.9999	0.9961	0.9980	0.9967
FIRST ORDER		0.9654	0.9518	0.9415	0.9461
HIXSON-CROWELL		0.9837	0.9716	0.9681	0.9691
HIGUCHI		0.9813	0.9929	0.9897	0.9921
KORSMEYER-PEPPAS		0.9235	0.9491	0.9413	0.9469
ZERO ORDER	II	0.9994	0.9999	0.9982	0.9965
FIRST ORDER		0.9912	0.9931	0.9861	0.9835
HIXSON-CROWELL		0.9950	0.9965	0.9913	0.9889
HIGUCHI		0.9973	0.9957	0.9989	0.9997
KORSMEYER-PEPPAS *		0.9841	0.9806	0.9885	0.9917
ZERO ORDER	III	0.9995	0.9990	0.9998	0.9996
FIRST ORDER		0.9905	0.9863	0.9935	0.9906
HIXSON-CROWELL		0.9950	0.9923	0.9971	0.9950
HIGUCHI		0.9884	0.9908	0.9838	0.9887
KORSMEYER-PEPPAS *		0.9655	0.9834	0.9725	0.9872
ZERO ORDER	IV	0.9987	0.9992	0.9944	1.0000
FIRST ORDER		0.9977	0.9982	0.9921	0.9996
HIXSON-CROWELL		0.9980	0.9986	0.9929	0.9998
HIGUCHI		0.9984	0.9977	1.0000	0.9950
KORSMEYER-PEPPAS *		/	/	/	/

* The model is considered valid for only up to 60% of the maximal total of the released drug.