Figure 1.

Modulation of IEGs expression following acute SEP-856 administration. The mRNA levels of Arc (A), c-Fos (B), Zif268/Egr1 (C) and Npas4 (D) were measured in different brain regions of rats treated with vehicle or SEP-856 (1, 3 or 10 mg/kg). The data, expressed as percentage of vehicle-treated rats set at 100%, are represented as box-and-whisker plots of at least four independent determinations. For each box, the box boundaries indicate the first and third quartiles, the middle line specifies the median and the whiskers represent the lowest and highest values. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. vehicle-treated rats (one-way ANOVA followed by Tukey post-hoc comparison).