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. 2021 Apr 26;21:460. doi: 10.1186/s12885-021-08210-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Functional enrichment analysis of KD genes. a, Functional enrichment analysis for KD genes using g:profiler online tool, including Gene Ontology (MF, BP, CC) and pathway (REAC and WP) in different colors. The Y axis represents -log10(Padj). b, The functions enriched by KD genes. The X axis represents -log10 (Padj), and the dotted line indicates Padj = 0.05. c, The semantic similarity between the functions enriched by KD genes and the known cancer hallmarks. d, The regulatory factors for KD genes confirmed by enrichment analysis. Blue indicates the number of KD genes, and orange indicates significance, −log10 (Padj)