Table 6.
Pubmatrix analysis of the top 10 statistically relevant pathways (p values < 0.05) obtained from the 3740-gene signature upregulated by the combined treatment hypoxia/PT with 10Gy. Glioblastoma Multiforme (GBM); radiotherapy (RT); proton therapy (PT); ionizing radiation (IR).
| PubMatrix | Hypoxia | GBM | RT | PT | Cancer | IR | Cell Death | Cell Cycle | Hif1-Alpha |
|---|---|---|---|---|---|---|---|---|---|
| PI3K-Akt signaling pathway | 1063 | 427 | 368 | 8 | 12,427 | 191 | 6798 | 3323 | 26 |
| Insulin signaling pathway | 591 | 89 | 82 | 8 | 6338 | 100 | 3505 | 2647 | 16 |
| Platelet activation | 584 | 136 | 151 | 101 | 5387 | 268 | 1651 | 1857 | 2 |
| Endocytosis | 384 | 245 | 274 | 107 | 13,851 | 391 | 6505 | 3903 | 2 |
| Wnt signaling pathway | 310 | 209 | 191 | 11 | 10,182 | 70 | 2563 | 2294 | 4 |
| Ras signaling pathway | 266 | 200 | 201 | 13 | 11,296 | 201 | 2907 | 3446 | 7 |
| Focal adhesion | 261 | 255 | 127 | 3 | 7394 | 91 | 1858 | 1874 | 3 |
| cAMP signaling pathway | 248 | 47 | 29 | 4 | 2908 | 117 | 1273 | 1490 | 6 |
| Proteoglycans in cancer | 195 | 284 | 339 | 11 | 13,155 | 81 | 1158 | 1299 | 4 |
| Protein processing in endoplasmic reticulum | 184 | 27 | 17 | 4 | 1676 | 27 | 1640 | 506 | 0 |