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A schematic showing the mechanism of curcumin inhibiting of LPA mediated MCP-1 expression. In VSMCs, LPA via LPAR5 transactivates the TGFBR1 in a ROCK dependent manner. LPA mediated MCP-1 expression is regulated by the TGFBR1 transactivation pathway. Curcumin blocks LPA mediated TGFBR1 transactivation and MCP-1 expression via inhibiting ROCK signalling.
