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. 2021 Apr 20;22(8):4255. doi: 10.3390/ijms22084255
  • The pathogenesis of DISH is unclear: polygenetic and epigenetic factors associated with metabolic disorders, with the probable contribution of genes from signaling pathways involved in bone formation (WNT, TGF β). DISH is usually asymptomatic.

  • DISHphagia: the failure of conservative treatments (pharmacotherapy, modification by changing eating habits, physiotherapy) is an indication for the surgical removal of the osteophyte.