The pathogenesis of DISH is unclear: polygenetic and epigenetic factors associated with metabolic disorders, with the probable contribution of genes from signaling pathways involved in bone formation (WNT, TGF β). DISH is usually asymptomatic.
DISHphagia: the failure of conservative treatments (pharmacotherapy, modification by changing eating habits, physiotherapy) is an indication for the surgical removal of the osteophyte.
|