Table 2.
Studies measuring psoas muscle mass using computed tomography in patients with chronic liver disease.
| Author (Year) | Country | Number of Subjects | Study Population | Measurement Method | Level of Measure | Cutoff for Sarcopenia | Method of Determining Cutoff |
|---|---|---|---|---|---|---|---|
| Englesbe (2010) [55] | USA | 163 | Cirrhosis patients undergoing LT | PMA | L4 | NR | Lowest quartiles |
| Krell (2013) [58] | USA | 207 | Adult patients undergoing LT | PMA | L4 | NR | Lowest tertile |
| Golse (2017) [54] | USA | 256 | Cirrhosis patients undergoing LT | PMA | L3-4 | Male: 1561 mm2
Female: 1464 mm2 |
ROC curve for 1-year mortality |
| Hamaguchi (2014) [56] | Japan | 200 | Adult patients undergoing LT | PMA/height2 | Umbilicus | Male: 6.868 cm2/m2
Female: 4.117 cm2/m2 |
ROC curve for mortality |
| Tsien (2014) [62] | USA | 53 | Adult patients undergoing LT | PMA/height2 | L4 | Age <50 years Male: 12.3 cm2/m2, Female: 10.5 cm2/m2 Age >50 years Male: 10.1 cm2/m2, Female: 10.3 cm2/m2 |
Age- and sex-specific 5th percentile values |
| Kalafateli (2017) [60] | UK | 232 | LT recipients | PMA/height2 | L3 | Male: 340 mm2/m2
Female: 264 mm2/m2 |
Lowest sex-stratified quartiles |
| Ebadi (2018) [57] | North America | 353 | Patients with cirrhosis on waiting list | PMA/height2 | L3 | Male: 5.1 cm2/m2
Female: 4.3 cm2/m2 |
ROC curve for waitlist mortality |
| Hou (2020) [59] | China | 251 | Cirrhotic patients | PMA/height2 | L3 | Male: 3.5 cm2/m2
Female: 2.6 cm2/m2 |
ROC curve for 3-year mortality |
| Ohara (2020) [61] | Japan | 318 | Chronic liver disease | PMA/height2 | L3 | (1) Male: 330 mm2/m2
Female: 169 mm2/m2 (2) Male: 374 mm2/m2 Female: 229 mm2/m2 |
(1) Less than 2 SD below the mean of normal control (2) The bottom 5% or normal control |
| Durand (2014) [52] | France | 562 | Patients with cirrhosis on waiting list | TPMT/height | Umbilicus | 16.8 mm/m | Youden index for waitlist mortality |
| Kim (2014) [14] | Korea | 65 | Decompensated cirrhosis | TPMT/height | L3–4 or umbilicus | 14 mm/m | ROC curve for 1-year mortality |
| Gu (2018) [33] | Korea | 653 | Cirrhotic patients | TPMT/height | Umbilicus | 16.8 mm/m | Previous reference |
| Huguet (2018) [53] | France | 173 | Cirrhotic patients on waiting list | TPMT/height | Umbilicus | 15.2 mm/m | ROC curve for mortality |
| Praktiknjo (2019) [63] | Europe | 186 | Patients with decompensated cirrhosis who underwent the TIPS | TPMT/height | Umbilicus | Male: 17.8 mm/m Female: 14.0 mm/m |
ROC curve for 1-year mortality |
Abbreviations: LT, liver transplantation; PMA, psoas muscle area; ROC, receiver operating characteristics; SD, standard deviation; TIPS, trans-jugular intrahepatic portosystemic shunt; TPMT, transversal psoas muscle thickness.