Table 3.
Association between piR-823 expression and clinicopathological characteristics in colorectal cancer cases.
| Tumor Tissue of CRC Cases | Serum of CRC Cases | ||||
|---|---|---|---|---|---|
| Parameter | No. of Cases (%) | piR-823 (Mean ± SD) | p Value | piR-823 (Mean ± SD) | p Value |
| Gender | 0.35 | 0.438 | |||
| - Male | 47 (56) | 3.3 ± 1.8 | 6.0 ± 2.2 | ||
| - Female | 37 (44) | 3.7 ± 2.1 | 6.4 ± 2.5 | ||
| Tumor Location | 0.51 | 0.334 | |||
| - Distal | 52 (62) | 3.3 ± 1.9 | 5.8 ± 2.4 | ||
| - Proximal | 32 (38) | 3.6 ± 2.2 | 6.3 ± 2.1 | ||
| TNM staging. | ** <0.001 | ** <0.001 | |||
| -Stage I, II | 44 (52.38) | 2.2 ± 2.9 | 5.3 ± 3.1 | ||
| -Stage III, IV | 40 (47.62) | 4.4 ± 1.5 | 7.5 ± 1.5 | ||
| Tumor Grading | 0.771 | 0.653 | |||
| - Grade 1, 2 | 67 (79.76) | 3.4 ± 2.7 | 6.1 ± 2.5 | ||
| - Grade 3 | 17 (20.24) | 3.6 ± 1.6 | 6.4± 2.2 | ||
| Differentiation | * 0.042 | ** <0.001 | |||
| -Well, Moderate | 60 (71.43) | 2.9 ± 2.2 | 3.5 ± 2.7 | ||
| -Poor | 24 (28.57) | 3.9 ± 1.4 | 9.2 ± 1.9 | ||
| Lymph node metastasis | 0.454 | * 0.031 | |||
| - Negative | |||||
| - Positive | 21 (25) | 3.2 ± 1.8 | 5.5 ±2.2 | ||
| 63 (75) | 3.6 ± 2.2 | 6.8 ± 2.4 | |||
| CEA | 0.525 | 0.7 | |||
| - Negative | 25 (29.76) | 3.6 ± 1.9 | 6.1 ±2.7 | ||
| - Positive | 59 (70.24) | 3.3 ± 2.0 | 6.3 ± 1.9 | ||
| CA 19-9 | 0.39 | 0.118 | |||
| - Negative | 44 (52.38) | 3.7 ± 1.2 | 5.8 ± 2.4 | ||
| - Positive | 40 (47.62) | 3.3 ± 2.8 | 6.6 ± 2.2 | ||
piR-823 level is in fold change, p-value for t-test, * statistically significant difference (p ≤ 0.05), ** statistically highly significant difference (p ≤ 0.001).