Figure 6.

Schematic representation of TPH104-mediated immunogenic cell death in MDA-MB-231 cells. TPH104 induces a unique, non-apoptotic cell death in TNBC cells and upregulates immunogenic biomarkers such as ATP and calreticulin. Further, TPH104-mediated death prompts these cells to produce TNF-α. The cumulative effect of these manifestations culminates in maturation and activation of inflammatory genes in BMDCs. Activation of DCs can cross-prime cytotoxic T cells to affect antitumor immunity targeting TNBC tumors for destruction.