Skip to main content
. 2021 Apr 16;10(4):915. doi: 10.3390/cells10040915

Figure 1.

Figure 1

Regulation of Small GTPase activity. The activity of small GTPases, including the Rho family, is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and guanine nucleotide dissociation inhibitors (GDIs). GEFs activate Rho GTPases by promoting GTP loading. The active, GTP-bound form of the Rho GTPase adopts a conformation that allows it to interact with effector proteins. GAPs inactivate Rho GTPases by stimulating GTP hydrolysis. GDIs prevent the activation of Rho GTPases by promoting cytosolic localization. Figure made with BioRender.