Figure 3.

Metabolic tissue distribution of mammalian Rho GEFs that are known to be involved in the regulation of glucose homeostasis. Nine mammalian Rho GEFs are currently known to regulate glucose homeostasis in vitro or in vivo. Their distribution in human metabolic tissues is shown here, as extracted from public database BioGPS (http://biogps.org, accessed on 10 April 2021) [74]. Data are mean mRNA expression values determined by Affymetrix microarray. Units are z-scores of mean fluorescence intensity, determined using multiple probes for each transcript and processed using gcrma algorithms. Genes with z-scores above 5, indicated by the stippled black line, are considered to be expressed in that tissue. The graph was drawn using GraphPad Prism 8.