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. 2021 Apr 16;10(4):925. doi: 10.3390/cells10040925

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A schematic diagram demonstrating how the transcription factor ZEB1 up- (green arrows) and down- (red arrows) regulates expression of genes and related corneal disorders. HAT, histone acetyltransferase; CtBP, C-terminal binding protein; HDAC, Histone deacetylase; NV, neovascularization; EMT, epithelial to mesenchymal transition; EnMT, endothelial to mesenchymal transition; LESC, limbal epithelial stem cell; KD, Keratoconus; FECD, Fuchs endothelial corneal dystrophy; PPCD, posterior polymorphous corneal dystrophy.