Figure 1.

Structural analyses of NS1. (A) Schematic representation of the full-length NS1 domain and of interacting proteins. NS1 consists of an RNA-binding domain (RBD), a linker region (LR), an effector domain (ED), and a C-terminal tail (CTT). RBD binds to dsRNA to inhibit the interferon (INF) induction, whereas the C-terminal ED region mediates interactions with several host cellular proteins. (B) NS1 dimer adapted from the X-ray structure of H6N6 NS1 (PDB ID: 4OPA), showing interactions between the two RBD.