Table 1.

Binding energy of hit compounds with Mtb proteasome (monomer and dimer).

Compound	Binding Energy (kcal/mol)		Inhibition Constant (µM)
	Monomer	Dimer	Monomer	Dimer
ZINC3875469	−7.19	−8.05	28.9	26.54
ZINC4076131	−7.95	−9.10	43.24	0.213
ZINC1883067	−7.21	−7.07	27.92	23.96
HT1171 *	−5.83	−5.97	45.36	47.01

* Positive control for Mtb proteasome.