Table 1.

Characteristics of the most used viral vectors in gene therapy for LSDs.

Vector	Size (nm)	Genome	Packaging Capacity (Kb)	Cell Type	Integration Profile
Retroviral	100	RNA	8	Dividing	Integrating
Lentiviral	100	RNA	14	Dividing and non-dividing	Integrating
Adenoviral	70–100	dsDNA	8–10	Dividing and non-dividing	Non-integrating
AAV	25–20	ssDNA	4.7	Dividing and non-dividing	Non-integrating