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. 2021 Apr 20;22(8):4278. doi: 10.3390/ijms22084278

Figure 1.

Figure 1

Figure 1

Differentially expressed circulating miRNAs were identified in urine from healthy volunteers and patients with bladder cancer using next-generation sequencing. (A) Flowchart of 10 NGS profiles. Circulating miRNAs with differential expression were filtered with a fold change of ≥2 or <0.25. (B) Heatmap presenting the upregulation or downregulation of circulating miRNAs in patients with bladder cancer. (C) Targets of differentially expressed miRNA candidates were identified using a target prediction tool and pathway enrichment analysis.