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Graphic representation of antiviral action of (E)-guggulsterone in DENV replication. (E)-guggulsterone effectively inhibits DENV replication through the Nrf2/HO-1 signaling pathway, blocks DENV NS2B/NS3 protease activity by stimulating the antiviral IFN response, and delays DENV-induced lethality of ICR suckling mice.
