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. Author manuscript; available in PMC: 2021 Apr 26.
Published in final edited form as: Neurochem Int. 2019 Dec 12;133:104642. doi: 10.1016/j.neuint.2019.104642

Table 3.

Therapeutic Potential of Epigenetic Modulators in Huntington’s Disease

Model Therapeutic Potential Modification Citation
mHTT Drosophila Selisistat improves survival and decreases cytotoxic inclusions Histone acetylation Smith et al., 2014
mHTT Drosophila AK1 and AGK2 are neuroprotective by way of sterol biosynthesis downregulation Histone acetylation Luthi-Carter et al., 2010
Htn-Q150 C. elegans Knockdown of HDA3 reduces polyglutamine toxicity Histone acetylation Bates et al., 2006
Tg-R6/2 mice HDACi 4b reverses H3 hypoacetylation and improves functional recovery Histone acetylation Thomas et al., 2008
HTT-Q73 PC12 cells miR-10b-5p mimic increases cell survival MiRNA Hoss et al., 2014
HTT-Q84 Neuroblastoma cells Overexpression of miR-196a increases neurite outgrowth MiRNA Fu et al., 2015
R6/2 mice MiR-132 overexpression provided neuroprotection and delayed disease progression MiRNA Fukuoka et al., 2018
Tg-R6/2 mice Overexpression of miR-196a enhances neurite outgrowths and improves learning and memory MiRNA Her et al., 2017
HD neural progenitor cells Overexpression of miR-196a normalized mitochondrial activity and decreased apoptosis MiRNA Kunkanjanawan, et al., 2016
STHdh(Q111)/Hdh(Q111) cells Exogenous expression of miR-146a, miR-432, and miR-19a reversed cell cycle defects and apoptosis MiRNA Das et al., 2015
STHdhQ7/HdhQ7 cells Overexpression of HYPK and Hsp70 reverses miR-125b, miR-146a, and miR-150 expressions while reducing mHTT aggregates MiRNA Ghose et al., 2011
Neuronal stem cells derived from R6/2 mice MiR-27a overexpression decreased mHTT aggregates MiRNA Ban et al., 2017
mHTT sheep HTT targeting by way of artificial miRNA safely reduces mHTT mRNA and protein MiRNA Pfister et al., 2018
Primary Striatal cell and cortical neurons, mHTT and 3-NP MiR-22 overexpression is neuroprotective MiRNA Jovicic et al., 2013
R6/2 neurons MiR-27a overexpression decreases mHTT aggregates by way of MDR-1 MiRNA Ban et al., 2017
Neuroblastoma cells, H2O2 Neat1 transfection increases tolerance to oxidative stress LncRNA Sunwoo et al., 2017
HEK293 cells and neuroblastoma cells Overexpression of HTTAS_v1 decreases HTT levels in a gene-specific manner LncRNA Chung et al., 2011
HHS Vulnerability Disclosure