Table 7.

Therapeutic Potential of Epigenetic Modulators in Epilepsy

Model	Therapeutic Potential	Modification	Citation
Wistar rats, pilocarpine	Ketogenic diet reduces global methylation and seizure severity	DNA methylation	Kobow et al., 2013
C57 mice, kainic acid	RG108 prevents RASgrf1 methylation and reduces seizures	DNA methylation	Chen et al., 2017
SD rats, kainic acid	Methionine restores BDNF methylation to improve memory	DNA methylation	Parrish et al., 2015
SD rats, pilocarpine	TSA reverses deacetylation of H4 at the GRIA2 promoter	Histone acetylation	Huang et al., 2002
WAG/Rij rats	Pretreatment of SB, VPA, or both reduces seizure severity	Histone acetylation	Citraro et al., 2019
C57 mice, hippocampus kindling	SB improves functional recovery and reduces epileptic morphology	Histone acetylation	Reddy et al., 2018
Human serum	Epilepsy can be predicted with 81% specificity by miRNA biomarkers	MiRNA	Wang et al., 2015
C57 mice, pilocarpine	miR-134 antagomir reduced number of mice that developed seizures and reduced severity in those that did	MiRNA	24874920
C57 mice, pentylenetetrazol	miR-134 antagomir reduces seizure severity and epileptic behavior	MiRNA	28325299
C57 mice, kainic acid	miR-132 antagomir reduces neurotoxicity after seizures	MiRNA	21945804
SD rats, kainic acid	Upregulating miR-124 has both anti-epileptic and pro-epileptic effects	MiRNA	26947066
SD rats, kainic acid	Inhibition of H19 prevents neurotoxicity after seizures	LncRNA	29795132