Table 2.
P-mtDNA and disease progression at 1-year follow-up
| Unadjusted | Adjusted for age & smoking status | |
|---|---|---|
| (CI)* | (CI)* | |
| FEV1% predicted | ||
| Alla | 0 (− 0.08, 0.07) | − 0.01 (− 0.09, 0.06) |
| Males | − 0.01 (− 0.1, 0.09) | − 0.01 (− 0.12, 0.09) |
| Male smokers | − 0.08 (− 0.25, 0.1) | − 0.08 (− 0.27, 0.1) |
| Male mild/mod | − 0.03 (− 0.23, 0.17) | − 0.05 (− 0.26, 0.15) |
| Male severe | 0.15 (− 0.07, 0.36) | 0.14 (− 0.08, 0.35) |
| Females | 0 (− 0.11, 0.11) | − 0.01 (− 0.12, 0.1) |
| Female smokers | 0.04 (− 0.16, 0.23) | 0.04 (− 0.16, 0.23) |
| Female mild/mod | − 0.09 (− 0.32, 0.15) | − 0.11 (− 0.35, 0.13) |
| Female severe | 0.10 (− 0.16, 0.36) | 0.08 (− 0.18, 0.34) |
| 6MWD (meters) | ||
| Alla | − 0.02 (− 0.1, 0.06) | − 0.01 (− 0.09, 0.07) |
| Males | 0.03 (− 0.07, 0.14) | 0.04 (− 0.07, 0.15) |
| Male smokers | − 0.01 (− 0.19, 0.16) | − 0.01 (− 0.18, 0.16) |
| Male mild/mod | − 0.06 (− 0.28, 0.16) | − 0.05 (− 0.27, 0.16) |
| Male severe | 0.27 (0.06, 0.48)b | 0.27 (0.05, 0.48) |
| Females | − 0.09 (− 0.21, 0.03) | − 0.09 (− 0.21, 0.04) |
| Female smokers | 0.03 (− 0.17, 0.22) | 0.03 (− 0.17, 0.22) |
| Female mild/mod | 0.08 (− 0.16, 0.32) | 0.08 (− 0.16, 0.32) |
| Female severe | − 0.33 (− 0.61, − 0.05)c | − 0.30 (− 0.59, − 0.02) |
| SGRQ | ||
| Alla | − 0.02 (− 0.1, 0.07) | − 0.03 (− 0.12, 0.06) |
| Males | − 0.02 (− 0.13, 0.09) | − 0.04 (− 0.16, 0.08) |
| Male smokers | − 0.07 (− 0.27, 0.13) | − 0.1 (− 0.3, 0.1) |
| Male mild/mod | 0 (− 0.2, 0.2) | 0 (− 0.2, 0.2) |
| Male severe | − 0.14 (− 0.39, 0.1) | − 0.16 (− 0.41, 0.08) |
| Females | − 0.02 (− 0.14, 0.11) | − 0.01 (− 0.14, 0.11) |
| Female smokers | − 0.15 (− 0.38, 0.08) | − 0.15 (− 0.38, 0.08) |
| Female mild/mod | 0.08 (− 0.2, 0.35) | 0.10 (− 0.18, 0.37) |
| Female severe | − 0.02 (− 0.29, 0.25) | − 0.10 (− 0.39, 0.18) |
| CAT | ||
| Alla | − 0.07 (− 0.15, 0.01) | − 0.07 (− 0.15, 0.02) |
| Males | − 0.01 (− 0.11, 0.09) | − 0.01 (− 0.11, 0.1) |
| Male smokers | 0.01 (− 0.16, 0.19) | 0.04 (− 0.14, 0.21) |
| Male mild/mod | − 0.08 (− 0.29, 0.13) | − 0.08 (− 0.29, 0.12) |
| Male severe | − 0.05 (− 0.26, 0.17) | − 0.05 (− 0.27, 0.17) |
| Females | − 0.15 (− 0.28, − 0.02) | − 0.14 (− 0.27, − 0.01) |
| Female smokers | − 0.28 (− 0.5, − 0.06) | − 0.30 (− 0.52, − 0.08) |
| Female mild/mod | − 0.29 (− 0.54, − 0.03) | − 0.27 (− 0.52, − 0.01) |
| Female severe | 0.05 (− 0.21, 0.31) | 0.03 (− 0.22, 0.29) |
r correlation coefficient, CI 95% confidence interval, FEV1 forced expiratory volume in 1 s, 6MWD six-minute walk distance, SGRQ St. George’s Respiratory Questionnaire, CAT COPD Assessment Test
*Pearson’s correlation coefficients with log2 p-mtDNA as among all participants and within each group
aAdjusting for age, sex, and smoking status
bItalic—statistically significant with positive correlation coefficient
cBold—statistically significant with negative correlation coefficient