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. 2021 Apr 26;21:209. doi: 10.1186/s12903-021-01544-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Effect of ProRoot^® MTA and Biodentine™ on odonto/osteogenic differentiation was evaluated. a ALP activity at day 10 after osteogenic induction and mineralization was examined using Von Kossa staining and alizarin red s staining at day 14. Scale bars indicate 40 μm. b The relative absorbance of the eluted alizarin red s dye. c The mRNA expression of odonto/osteogenic differentiation markers (RUNX2, DMP1, DSPP, and OCN) was examined using real-time polymerase chain reaction at day 4 and 10. Bars indicate a significant difference (Mann Whitney U test, p < 0.05)