Table 3.

Study 1: Efficacy of ProHeart 12 compared to Heartgard^® Plus or Interceptor^® Plus against the JYD-34 heartworm strain: Day −30 inoculation, adult heartworm AG and MF results

Treatment	Dosage	Days of treatment	Number of infected dogsa, b	No. dogs positive for adult heartworm AGc		No. dogs positive for MF
				Day 151 (181 days PI)	Day 178 (208 days PI)	Day 151 (181 days PI)	Day 178 (208 days PI)
Negative control	NA	0	6 of 6	6 of 6	6 of 6	4 of 6	6 of 6
ProHeart 12	0.5 mg/kg moxidectind	0	0 of 5	0 of 5	0 of 5	0 of 5	0 of 5
Heartgard Plus	Min. of 6 µg/kg ivermectine	0, 30, 60, 90, 120, 150	6 of 6	5 of 6f	6 of 6g	5 of 6	6 of 6
Interceptor Plus	Min. of 0.5 mg/kg milbemycin oximeh	0, 30, 60, 90, 120, 150	6 of 6	6 of 6	6 of 6	6 of 6	6 of 6

^aEach dog was inoculated with 50 D. immitis third-stage larvae (JYD-34 strain) on day −30

^bAll dogs were necropsied for recovery of adult D. immitis on day 185 (215 days PI; 35 days after the last treatment with Heartgard^® Plus and Interceptor^® Plus)

^cDiroCHEK

^dProHeart 12 (moxidectin extended-release injectable suspension) administered according to commercial label directions which resulted in a point administration of 0.5 mg/kg of moxidectin to each dog. One dog in the ProHeart 12 group was euthanized on day 90 due to an abnormal health event unrelated to drug treatment

^eHeartgard Plus (ivermectin + pyrantel) administered according to commercial label directions which resulted in administration of from 6.6 to 11.2 µg/kg of ivermectin

^fTwo of six dogs positive only after heat treatment; positive on both DiroCHEK and Snap4DX Plus

^gTwo of six dogs positive only after heat treatment; positive on both DiroCHEK and Snap4DX Plus

^hInterceptor Plus (milbemycin oxime + praziquantel) administered according to commercial label directions which resulted in administration of from 0.52 to 1.0 mg/kg milbemycin oxime