Table 5.

Study 1: Efficacy of ProHeart 12 compared to Heartgard Plus or Interceptor Plus against the JYD-34 heartworm strain: Day −30 inoculation, adult heartworm counts and percentage reductions

Treatment	Dosage	Days of treatment	Number of infected dogs a	Adult D. immitis worm counts		Efficacy compared to negative control c
				Individual worm counts	Geometric mean b	Percentage reduction
Negative control	NA	0	6 of 6	23, 25, 29, 33, 35, 37	29.9g	NA
ProHeart 12	0.5 mg/kg moxidectin d	0	0 of 5	0	0h	100
Heartgard Plus	Min. of 6 µg/kg ivermectin e	0, 30, 60, 90, 120, 150	6 of 6	19, 21, 24, 33, 34, 34	26.8g	10.5
Interceptor Plus	Min. of 0.5 mg/kg milbemycin oxime f	0, 30, 60, 90, 120, 150	6 of 6	13, 24, 27, 30, 31, 35	25.5g	14.6

^aEach dog was inoculated with 50 D. immitis third-stage larvae (JYD-34 strain) on day −30

^bGeometric mean counts with different superscript letters are significantly different (P < 0.0001), see ^{g, h,}

^cAll dogs were necropsied for recovery of adult D. immitis on day 185 (215 days PI; 35 days after the last treatment with Heartgard Plus and Interceptor Plus)

^dProHeart 12 (moxidectin extended-release injectable suspension) administered according to commercial label directions which resulted in a point administration of 0.5 mg/kg of moxidectin to each dog. One dog in the ProHeart 12 group was euthanized on day 90 due to an abnormal health event unrelated to drug treatment

^eHeartgard Plus (ivermectin + pyrantel) administered according to commercial label directions which resulted in administration of from 6.6 to 11.2 µg/kg of ivermectin

^fInterceptor Plus (milbemycin oxime + praziquantel) administered according to commercial label directions which resulted in administration of from 0.52 to 1.0 mg/kg milbemycin oxime