Table 6.

Study 2: Efficacy of ProHeart 12 compared to Heartgard Plus or Interceptor Plus against the JYD-34 heartworm strain: Day 165 inoculation, adult heartworm counts and percentage reductions

Treatment	Dosage	Days of treatment	Number of infected dogsa	Adult D. immitis worm counts		Efficacy compared to negative control c
				Individual worm counts	Geometric meanb	Percentage reduction
Negative control	NA	0	6 of 6	27, 32, 34, 36, 37, 46	34.9g	NA
ProHeart 12	0.5 mg/kg moxidectin d	0	4 of 6	0, 0, 1, 1, 1, 1	0.6h	98.3
Heartgard Plus	Min. of 6 µg/kg ivermectine	0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330	6 of 6	12, 20, 23, 24, 27, 29	21.7i	37.7
Interceptor Plus	Min. of 0.5 mg/kg milbemycin oximef	0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330	6 of 6	14, 19, 23, 24, 25, 37	22.7i	34.9

^aEach dog was inoculated with 50 D. immitis third-stage larvae (JYD-34 strain) on day 165

^bGeometric mean counts with different superscript letters are significantly different (P ≤ 0.0321), see ^{g, h, i}

^cAll dogs were necropsied for recovery of adult D. immitis on day 360 (195 days PI; 30 days after the last treatment with Heartgard Plus and Interceptor Plus)

^dProHeart 12 (moxidectin extended-release injectable suspension) administered according to commercial label directions which resulted in a point administration of 0.5 mg/kg of moxidectin to each dog

^eHeartgard Plus (ivermectin + pyrantel) administered according to commercial label directions which resulted in administration of 6.5 to 11.5 µg/kg of ivermectin

^fInterceptor Plus (milbemycin oxime + praziquantel) administered according to commercial label directions which resulted in administration of 0.51 to 1.1 mg/kg milbemycin oxime