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. 2021 Apr 26;16:28. doi: 10.1186/s13024-021-00448-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Correlation analyses between [¹⁸F]BCPP-EF SUVR and [¹¹C]PBB3 BP_ND, [¹¹C] PiB SUVR, or neuropsychological battery scores in the Braak stage III-IV region of interest (ROI) in patients with AD. a Brain area of Braak stage III-IV ROI overlaid on the Montreal Neurological Institute 152 reference template. b The regional [¹⁸F]BCPP-EF SUVR in AD (n = 32) was significant lower than that in the controls (n = 17). c The regional [¹¹C]PBB3 BP_ND in AD (n = 32) was significant higher than that in the controls (n = 18). d, e There was no significant negative correlation of [¹⁸F] BCPP-EF SUVR with [¹¹C]PBB3 BP_ND (n = 16) or [¹¹C] PiB SUVR (n = 32). f, g, h There was significant positive correlation of [¹⁸F] BCPP-EF SUVR with Mini-Mental Examination score (n = 32) or Frontal Assessment Battery score (n = 25), but not Wechsler Memory Scale-Revised logical memory score (n = 25). i, j, k There was no significant positive correlation of [¹¹C]PBB3 BP_ND with Mini-Mental Examination score, Wechsler Memory Scale-Revised logical memory score, or Frontal Assessment Battery score (n = 16)