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. 2021 Apr 26;19:167. doi: 10.1186/s12967-021-02818-1

Table 1.

Patient clinical characteristics

Total C0 C1 PDCA MDCA C3 C4 P valuea Without severe Myopic Maculopathy (MM) Severe MM P valueb
Eye # (%) 457 44(9.6) 112(24.5) 122(26.7) 104(22.8) 45(9.8) 30(6.6) / 278 179 /
Age in yrs 67.9 ± 6.3 64.6 ± 5.7 67.6 ± 5.2 67.4 ± 6.1 69.1 ± 7 69 ± 6.3 70.5 ± 7.6 < 0.001 67 ± 5.7 69.3 ± 6.9  < 0.001
Men (%) 191(41.8) 27(61.4) 47(42.0) 54(44.3) 42(40.4) 13(28.9) 8(26.7) 0.021 128(46.0) 63(35.2) 0.025
SER, D − 9.34 ± 5.65 − 6.17 ± 3.09 − 8.27 ± 4.85 − 8.9 ± 4.82 − 11.83 ± 6.34 − 9.88 ± 6.7 − 10.28 ± 6.8 < 0.001 − 8.21 ± 4.68 − 11.08 ± 6.53 < 0.001
AL, mm 28.53 ± 1.85 26.71 ± 0.53 27.62 ± 1.37 28.18 ± 1.65 29.62 ± 1.68 30.26 ± 1.4 29.63 ± 1.74 < 0.001 27.72 ± 1.49 29.79 ± 1.64 < 0.001
BCVA (logMAR) 0.46 ± 0.37 0.16 ± 0.14 0.35 ± 0.29 0.42 ± 0.34 0.6 ± 0.38 0.59 ± 0.41 0.95 ± 0.35 < 0.001 0.35 ± 0.31 0.64 ± 0.4 < 0.001
Tilt ratio 0.70 ± 0.13 0.78 ± 0.1 0.7 ± 0.14 0.72 ± 0.12 0.65 ± 0.13 0.63 ± 0.13 0.66 ± 0.11 < 0.001 0.72 ± 0.13 0.65 ± 0.13 < 0.001
Torsion0 − 2.89 ± 33.72 6.52 ± 46.43 − 5.43 ± 34.44 − 1.43 ± 41.04 − 5.35 ± 23.94 − 0.16 ± 20.67 − 8.76 ± 14.06 0.303 − 1.78 ± 39.52 − 4.62 ± 21.85 0.326
PPA area (mm2) 2.27 ± 2.18 0.52 ± 0.34 1.45 ± 1.16 1.53 ± 1.14 3.52 ± 2.59 4.15 ± 2.86 3.77 ± 2.12 < 0.001 1.34 ± 1.12 3.72 ± 2.59 < 0.001

AL axial length, BCVA   best-corrected visual acuity, C0  no myopic maculopathy; C1   tessellated fundus, C3  patchy atrophy, C4   macular atrophy, D  diopter, logMAR   logarithm of minimal angle of resolution, MDCA   macular diffuse choroidal atrophy, PDCA   peripapillary diffuse choroidal atrophy, PPA  peripapillary atrophy, SER  spherical equivalent refraction; Eyes with C0, C1 and PDCA were classified as without severe MM, eyes with MDCA, C3 and C4 were classified as severe MM

aP value for the difference in characteristics between different degree of myopic maculopathy, based on One-way ANOVA test or x2 test, as appropriate

bP value for the difference in characteristics between eyes with and without severe MM, based on Student’s t-test or x2 test, as appropriate