Fig. 7.

Molecular docking analysis of heparin against spike protein (Closed state RBD) of SARS-CoV-2 envelope with different mutations. Position/location of the heparin molecule is pointed out with a circular purple ligand symbol. The trimeric protein complex had three mutant structures from PDB (7AD1, 7NDB, and 7KDL) and supercomputer predicted structures for mutants from UK, Brazil, South Africa, and Danish minks with differences in vaccine efficacies reported recently (Table 3). All the structure showed strong binding with closed state RBD. Lower docking score observed with Danish mink might not be necessarily be due to mutation but could be due to flexible state of the relatively large trimeric complex and also predicted structures might lack proper glycosylation's that seem to play an important role in spike stabilizations as seen in wild type structure 7CAI. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)