Table 1.
Biological activity values against the SARS-CoV-2 virus of some small molecules with the corresponding protein targets.
| Cpd. | Target | Biological activity | Ref. (PMID) |
|---|---|---|---|
| 1 (N3) | Mpro | not reported | [228] |
| 2 (Ebselen) | Mpro | 0.67 μM | [228] |
| 3 (Disulfiram) | Mpro | 9.35 μM | [228] |
| 4 (Tideglusib) | Mpro | 1.55 μM | [228] |
| 5 (Carmofur) | Mpro | 1.82 μM | [228] |
| 6 (Shikonin) | Mpro | 15.75 μM | [228] |
| 7 (PX-12) | Mpro | 21.39 μM | [228] |
| 8 (TDZD-8) | Mpro | 2.15 μM | [228] |
| 9 (Cinanserin) | Mpro | 125 μM | [228] |
| 10 | Mpro | 0.053 μM | [230] |
| 11 | Mpro | 0.04 μM | [230] |
| 12 (Manidipine) | Mpro | 4.8 μM | [231] |
| 13 (Boceprevir) | Mpro | 5.4 μM | [231] |
| 14 (Lercanidipine) | Mpro | 16.2 μM | [231] |
| 15 (Efonidipine) | Mpro | 38.5 μM | [231] |
| 16 (Bedaquiline) | Mpro | 18.7 μM | [231] |
| 17 (Carprofen) | Mpro | 3.97% | [232] |
| 18 (Celecoxib) | Mpro | 11.97% | [232] |
| 19 (Lumacaftor) | Nsp13 | 0.3 mM | [233] |
| 20 (Cepharanthine) | Nsp13 | 0.4 mM | [233] |
| 21 (Baricitinib) | AAK1 | 8.2 nM | [234], [235], [237] |
| 21 (Baricitinib) | BIKE | 20 nM | [234], [235], [237] |
| 21 (Baricitinib) | GAK | 120 nM | [234], [235], [237] |
| 22 (Diminazene) | Furin and Spike protein cleavage | 5.42 μM | [243] |
| 23 | Phenotypic screening | 0.5 μM | [244] |
| 24 (Hypericin) | Mpro | 63.6 μM | [245] |
| 25 (Cyanidin-3-O-glucoside) | Mpro | 65.1 μM | [245] |
| 26 (SRT2104) | Mpro | 85.0 μM | [245] |
| 27 (Amiodarone) | Phenotypic screen (SARS-CoV-2) | 52 nM | [247] |
| 28 (Bosutinib) | Phenotypic screen (SARS-CoV-2) | 20 nM | [247] |
| 29 (Clofazimine) | Phenotypic screen (SARS-CoV-2) | 84 nM | [247] |
| 30 (Entecavir) | Phenotypic screen (SARS-CoV-2) | 42 nM | [247] |
| 31 (Fedratinib) | Phenotypic screen (SARS-CoV-2) | 24 nM | [247] |
| 32 (Gilteritinib) | Phenotypic screen (SARS-CoV-2) | 224 nM | [247] |
| 33 (Lactoferrin) | Phenotypic screen (SARS-CoV-2) | 308 nM | [247] |
| 34 (Lomitapide) | Phenotypic screen (SARS-CoV-2) | 766 nM | [247] |
| 35 (Metoclopramide) | Phenotypic screen (SARS-CoV-2) | 468 nM | [247] |
| 36 (Niclosamide) | Phenotypic screen (SARS-CoV-2) | 142 nM | [247] |
| 37 (Remdesivir) | Phenotypic screen (SARS-CoV-2) | 97 nM | [247] |
| 38 (S1RA) | Phenotypic screen (SARS-CoV-2) | 222 nM | [247] |
| 39 (Thioguanine) | Phenotypic screen (SARS-CoV-2) | 22 nM | [247] |
| 40 (Verapamil) | Phenotypic screen (SARS-CoV-2) | 533 nM | [247] |
| 41 (Z-FA-FMK) | Phenotypic screen (SARS-CoV-2) | 107 nM | [247] |
| 42 (GC376) | Mpro | 26.4 nM | [248] |
| 43 (Quercetin) | Mpro | 7 μM | [249] |