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. 2021 Apr 20:1–12. doi: 10.1080/07391102.2021.1910570

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Figure 8. — Physicochemical and BBB permeability of NAPQI and acetaminophen. The diagram of physicochemical properties including: lipophilicity, LIPO; molecular size, SIZE; polarity, POLAR; insolubility, INSOLU; instauration, INSATU; molecular flexibility, FLEX, of NAPQI (A) and acetaminophen (B). The BOILED-Egg plot (C), an estimation of NAPQI or acetaminophen permeation into BBB (yellow yolk area), and intestine (white oval area). BBB, blood-brain-barrier; HIA, human intestinal absorption; WLOGP, the log P method developed by Wildman and Crippen; TPSA, topological polar surface area; PGP, P-glycoprotein.